ER Protein Quality Control
Gene co-expression module in Mast cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 14 genes have a known function matching the annotation |
Why this annotation
VCP (p97/CDC48) is a central AAA-ATPase driving ER-associated degradation (ERAD) and protein quality control. RPN1 is a core component of the ER translocon (OST complex). ESYT2 mediates ER-plasma membrane contact sites for lipid transfer. EOLA2 is an ER oxidoreductase. CUL1 forms the SCF ubiquitin ligase complex for proteasomal degradation. UBAP1 is ubiquitin-associated. HNRNPL is an RNA-binding protein. NR1D2 (REV-ERBβ) is a circadian nuclear receptor. RABGEF1 regulates early endosome dynamics. The dominant theme is ER protein processing and ubiquitin-proteasome quality control.
Genes
Most correlated modules
- NF-κB Stress Signaling · correlation 0.94
- Circadian Transcription · correlation 0.93
- Inflammatory IRAK3-BATF Response · correlation 0.93
- PI3K-Wnt Signaling · correlation 0.92
- Innate Immune Stress · correlation 0.92
- Tryptase Expression Mixed · correlation 0.90
- Cellular Housekeeping Mixed · correlation 0.89
- Transcriptional Metabolic Regulation · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.