Nuclear gene expression
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 22 genes have a known function matching the annotation |
Why this annotation
This low-expression module (15% detection, uniform) mixes nuclear housekeeping genes with no shared pathway: transcription (TAF6), RNA exosome (EXOSC1), chromatin (HELLS, PSIP1), kinetochore (ZWILCH), chaperonin (CCT6B), splicing (SNRPN) and translation reinitiation (MCTS1). HELLS and ZWILCH hint weakly at proliferation, but no core mitotic markers are present. It most likely reflects sparse, detection-driven co-variation of nuclear housekeeping genes.
Genes
Most correlated modules
- DNA replication/repair · correlation 0.83
- Ribosome biogenesis · correlation 0.77
- RNA/DNA processing · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.