DNA replication/repair
Gene co-expression module in Monocytes
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 35 genes have a known function matching the annotation |
Why this annotation
This low-expression module contains DNA replication/repair and mitotic genes: MMS22L (replication fork stability), TFDP2 (E2F partner), SMC4 (condensin), RNF168 (DNA damage ubiquitination), ZNF367 (E2F-regulated), DSN1 (kinetochore) and NME7 (centrosome). Together these suggest a small proliferating/replicating fraction. The many peripheral genes make this interpretation tentative.
Genes
Most correlated modules
- Generic housekeeping metabolism · correlation 0.84
- Nuclear gene expression · correlation 0.83
- Actin-endocytic remodeling · correlation 0.83
- Leukocyte endothelial adhesion · correlation 0.81
- Classical monocyte identity · correlation 0.76
- FOXO1 quiescence program · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.