TGF-beta tissue adaptation
Gene co-expression module in Monocytes
| Category | Tissue adaptation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 12 of 21 genes have a known function matching the annotation |
Why this annotation
This module contains TGFBR2, ADAM10, CTSS, EGLN1, FOXP1, TMEM154, ARHGAP15, ST3GAL1 and CPQ. Together these suggest monocyte-to-macrophage tissue adaptation, with TGF-beta responsiveness and antigen-processing cathepsin S, alongside lipid transfer (OSBPL8). ACSM1/ACSM3 have weak membership and may be peripheral. Coherence is moderate overall.
Genes
Most correlated modules
- Classical monocyte antibacterial · correlation 0.81
- MAPK/Ca2+ signaling machinery · correlation 0.81
- Chromatin regulator transcripts · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.