MAPK/Ca2+ signaling machinery
Gene co-expression module in Monocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 21 genes have a known function matching the annotation |
Why this annotation
The core is intracellular signaling genes: MAPK1, MAP3K1, FYN, STIM1 (store-operated Ca2+ entry), BCR (RhoGAP/kinase), FGD3 (Cdc42 GEF), IPMK and PDK1. These are mixed with transcriptional repressors and chromatin regulators (TLE4, ARID3A, KDM5B, MIER1). Expression is uniform and highly detected, consistent with a constitutive signaling-machinery program rather than an acute activation state, since no immediate early genes or cytokines are present. It neighbors the chromatin and long-gene modules M26 and M116, supporting a shared basal transcriptional layer.
Genes
Most correlated modules
- Chromatin regulator transcripts · correlation 0.82
- TGF-beta tissue adaptation · correlation 0.81
- Classical monocyte antibacterial · correlation 0.80
- Integrin adhesion signaling · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.