Classical monocyte antibacterial
Gene co-expression module in Monocytes
| Category | Innate immunity |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 27 genes have a known function matching the annotation |
Why this annotation
SLC11A1 (NRAMP1, a phagosomal metal transporter), IRAK3 (TLR negative regulator), CD55, PRAM1, MOSPD2, STK17B and VMP1 point to a classical monocyte/neutrophil-like innate effector program. This program includes phagosomal antibacterial defense and TLR tolerance. It is distinct from its technical-looking neighbors, though co-expressed with them in the same monocyte state.
Genes
Most correlated modules
- Neutrophil-like monocytes · correlation 0.83
- Recruited monocyte program · correlation 0.81
- Endosomal trafficking regulators · correlation 0.81
- TGF-beta tissue adaptation · correlation 0.81
- MAPK/Ca2+ signaling machinery · correlation 0.80
- Classical monocyte alarmins · correlation 0.69
- Classical monocyte degranulation · correlation 0.68
- Integrin adhesion signaling · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.