Co-chaperone Proteostasis
Gene co-expression module in Monocytes
| Category | Stress |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 11 genes have a known function matching the annotation |
Why this annotation
BAG3 (HSP70 co-chaperone linking to autophagy), HSPB1 (HSP27, small heat shock protein), HSPA6 (stress-inducible HSP70 family), FKBP4 (HSP90 co-chaperone/immunophilin), STIP1/HOP (HSP70-HSP90 organizing protein), AHSA1 (HSP90 ATPase activator), SERPINH1 (HSP47, collagen chaperone), CACYBP (calcyclin-binding protein, ubiquitin pathway), ZFAND2A (AIRAP, stress-induced proteasome regulator). This module represents the co-chaperone and proteostasis network, distinct from but neighboring M82's canonical HSPs. Strongly upregulated in CD inflammation. ALAS1 is less clearly linked but can be stress-induced.
Genes
AHSA1, ALAS1, BAG3, CACYBP, FBXL14, FKBP4, HSPA6, HSPB1, SERPINH1, STIP1, ZFAND2A
Most correlated modules
- Heat Shock Response · correlation 0.84
- ER Stress Response · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.