Endosomal Vesicle Trafficking
Gene co-expression module in Neutrophils
| Category | Vesicular traficking |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
This core-coherence, uniformly expressed 12-gene module in neutrophils contains several vesicular trafficking and endolysosomal regulators. WDFY3 (ALFY) is a key autophagy scaffold that directs cargo to autophagosomes; PICALM is a clathrin-assembly protein central to clathrin-mediated endocytosis; USP32 is a deubiquitinase localizing to late endosomes/lysosomes; USP3 deubiquitinates histone H2A and has roles in DNA damage but also trafficking; OSBPL8 (ORP8) is an oxysterol-binding protein on late endosomes regulating lipid transfer; WDFY3 and PICALM together strongly anchor this module in endocytic/autophagic vesicle trafficking. TBXAS1 (thromboxane synthase) is expressed in neutrophils and related to arachidonic acid metabolism and lipid mediator production. SLC12A6 (KCC3) is a K-Cl cotransporter. DIP2B and PCNX1 are less well characterized. JAK1 suggests some cytokine signaling input. ELF2 is a transcription factor. NRDC is a metalloendopeptidase. The dominant signal from top hub genes (WDFY3, PICALM, USP32, OSBPL8) is vesicular trafficking — specifically endosomal/autophagic membrane traffic. TBXAS1 adds a lipid metabolism flavor. Neighbor context (M30 with cytoskeletal/GTPase content, M48 with kinase/ubiquitin content) is consistent with a shared regulatory/homeostatic neighborhood.
Genes
DIP2B, ELF2, JAK1, NRDC, OSBPL8, PCNX1, PICALM, SLC12A6, TBXAS1, USP3, USP32, WDFY3
Most correlated modules
- Granulopoiesis Transcriptional · correlation 0.98
- Endocytic Vesicle Trafficking · correlation 0.97
- Actin Cytoskeletal Remodeling · correlation 0.96
- ER Stress Response · correlation 0.96
- Cytoskeletal Remodeling · correlation 0.96
- Stress Kinase Signaling · correlation 0.95
- PI3K Migration Signaling · correlation 0.95
- Ubiquitin Regulatory Signaling · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.