Neutrophils: gene co-expression modules
Short-lived granulocytes, the first responders mobilised from marrow; kill microbes through phagocytosis, reactive oxygen, and extracellular traps, at the cost of collateral tissue damage.
SCUBA's reference network for Neutrophils holds 72 gene modules covering 820 genes. Each module is a group of genes that rise and fall together across these cells, annotated with the biological process it most likely represents.
Antibacterial (1)
- TLR5 Bacterial Sensing · 12 genes
Antiviral (3)
- IFN-gamma Response · 13 genes
- Innate DNA Sensing ISG · 10 genes
- Interferon Stimulated Genes · 10 genes
Cell cycle (2)
- Mitotic Spindle · 13 genes
- S-G2-M Cell Cycle · 10 genes
Chemotaxis (3)
- ELMO-DOCK Chemotaxis · 8 genes
- Neutrophil Chemotaxis Receptors · 9 genes
- PI3K Chemotaxis Signaling · 15 genes
Cytokine & chemokine secretion (3)
- CC Chemokine Secretion · 13 genes
- Chemokine Secretion · 12 genes
- Inflammasome IL-1 Response · 14 genes
Cytoskeletal (3)
- Actin Cytoskeletal Remodeling · 18 genes
- Actin Cytoskeleton Dynamics · 15 genes
- Cytoskeletal Remodeling · 11 genes
Degranulation (4)
- Degranulation Trafficking · 16 genes
- Primary Granule Antimicrobial · 10 genes
- Secondary Granule Antibacterial · 12 genes
- Specific Granule Release · 8 genes
Developmental (13)
- Apoptotic Neutrophil Program · 14 genes
- Freshly infiltrated neutrophils · 12 genes
- Granulopoiesis Program · 14 genes
- Granulopoiesis Transcriptional · 8 genes
- Immature Granulocyte Progenitor · 12 genes
- Immature Neutrophil Granule · 9 genes
- Mature Neutrophil Identity · 8 genes
- Mature Neutrophil Identity · 10 genes
- Myeloid Lipid Remodeling · 12 genes
- Myeloid Maturation · 8 genes
- Neutrophil Differentiation · 10 genes
- Neutrophil Differentiation · 11 genes
- Neutrophil Survival FOXO-MK2 · 10 genes
Housekeeping (11)
- General Homeostatic Regulation · 8 genes
- Glycolytic Metabolism · 13 genes
- mRNA Splicing Processing · 17 genes
- Myeloid Identity · 12 genes
- Pentose Phosphate Pathway · 10 genes
- Proteostasis RNA Metabolism · 9 genes
- RNA Splicing · 8 genes
- Translation Initiation · 10 genes
- Translational Housekeeping · 9 genes
- Ubiquitin Regulatory Signaling · 9 genes
- Ubiquitin-Proteasome Turnover · 19 genes
Inflammatory (8)
- Inflammasome Signaling Regulation · 8 genes
- JAK-MAPK Signaling · 10 genes
- Myeloid Inflammatory Activation · 14 genes
- Neutrophil Survival Program · 11 genes
- NF-κB Activation · 15 genes
- NF-κB Inflammatory Transcription · 19 genes
- NF-κB Signaling · 11 genes
- S100 Alarmin Response · 9 genes
Innate immunity (5)
- C5aR Complement Activation · 12 genes
- Mature Neutrophil Activation · 10 genes
- Signal Attenuation · 9 genes
- TLR Lipid Signaling · 10 genes
- TLR2 Innate Signaling · 13 genes
Migration & adhesion (3)
- Neutrophil Adhesion Signaling · 8 genes
- Neutrophil Motility Cytoskeleton · 18 genes
- PI3K Migration Signaling · 12 genes
Netosis (1)
- NET Priming State · 10 genes
Phagocytosis (2)
- Bacterial Phagocytosis Program · 10 genes
- Phagocytic Membrane Signaling · 18 genes
Stress (6)
- ER Stress Response · 8 genes
- Heat Shock Response · 13 genes
- Immediate Early Response · 8 genes
- Inflammatory Resolution · 13 genes
- KLF2 Survival Response · 10 genes
- Stress Kinase Signaling · 11 genes
Vesicular traficking (4)
- Endocytic Vesicle Trafficking · 10 genes
- Endocytic Vesicular Trafficking · 9 genes
- Endosomal Vesicle Trafficking · 8 genes
- Endosomal Vesicle Trafficking · 12 genes