C5aR Complement Activation
Gene co-expression module in Neutrophils
| Category | Innate immunity |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
C5AR1 (C5aR/CD88) is the complement C5a receptor, a major neutrophil activating and chemotactic GPCR. PFKFB3 is induced during inflammatory activation and drives glycolytic reprogramming supporting neutrophil effector function. MCL1 is an anti-apoptotic protein that extends neutrophil lifespan during activation. SAMSN1 is an SH3 adaptor expressed in myeloid cells regulating B cell and neutrophil activation. CD55 is a complement regulatory protein. LAPTM5 links to lysosomal activity. THEMIS2 modulates immune receptor signaling. PTPRE regulates neutrophil integrin signaling. The C5aR-MCL1-PFKFB3 axis indicates complement-triggered neutrophil activation with metabolic and survival adaptation.
Genes
ADGRG3, C5AR1, CD55, ITPRIP, LAPTM5, MCL1, PFKFB3, PTPRE, RYBP, SAMSN1, THEMIS2, TPM4
Most correlated modules
- NF-κB Inflammatory Transcription · correlation 0.89
- TLR2 Innate Signaling · correlation 0.87
- Neutrophil Survival FOXO-MK2 · correlation 0.85
- Myeloid Inflammatory Activation · correlation 0.85
- PI3K Chemotaxis Signaling · correlation 0.84
- Interferon Stimulated Genes · correlation 0.79
- Ubiquitin Regulatory Signaling · correlation 0.78
- Neutrophil Adhesion Signaling · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.