RNA-binding regulation
Gene co-expression module in Neutrophils
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 17 genes have a known function matching the annotation |
Why this annotation
A small, weak module whose hubs are RNA-binding and translation-regulation genes (PUM1, RBM25, PABPC1, SFPQ, SCAF1). It also contains scattered housekeeping genes such as SMS, MRPS6, POLR1D and SIN3A, and ubiquitin ligases (HUWE1, RNF168). Expression is uniform, with no lineage or neutrophil-specific signal, consistent with generic RNA-processing detection covariance.
Genes
Most correlated modules
- mRNA splicing · correlation 0.56
- Ubiquitin proteostasis · correlation 0.54
- mRNA Splicing/Processing · correlation 0.47
- mRNA turnover regulation · correlation 0.46
- MHC-I Antigen Presentation · correlation 0.45
- Proteasome/signalosome maintenance · correlation 0.38
- Generic Housekeeping · correlation 0.36
- IL-1 Activation · correlation 0.32
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.