Inflammatory mediator secretion
Gene co-expression module in Neutrophils
| Category | Cytokine & chemokine secretion |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 27 genes have a known function matching the annotation |
Why this annotation
CXCL1, OSM, PTGS2, OLR1, AREG and THBD reflect an inflammatory effector-secretion program in activated tissue neutrophils. Early-response genes in the module (CSRNP1, NR4A3, FOSL2, ELL2) support this activation. The partial overlap with immediate-early genes in M83 is noted, but the secreted mediators dominate.
Genes
Most correlated modules
- Microbial Metabolite Sensing · correlation 0.59
- TNF-NFkB response · correlation 0.55
- TLR-NFkB signaling · correlation 0.50
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.