TNF-NFkB response
Gene co-expression module in Neutrophils
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 14 of 32 genes have a known function matching the annotation |
Why this annotation
The module contains classic NF-kB targets: TNFAIP2, TNFAIP6, NFKB2, NFKBIE, REL, PIM2, SOD2, KDM6B, IER5 and N4BP1. Alongside these sit AQP9 and MARCKS, which mark activated neutrophils, and NFE2L2. This is the TNF/LPS-induced NF-kB effector program and the downstream partner of M35.
Genes
Most correlated modules
- TLR-NFkB signaling · correlation 0.69
- IFN/NF-kB activation · correlation 0.58
- cAMP-CREB stress response · correlation 0.58
- MHC-I Antigen Presentation · correlation 0.56
- Inflammatory mediator secretion · correlation 0.55
- Microbial Metabolite Sensing · correlation 0.39
- Interferon-stimulated genes · correlation 0.36
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.