Myeloid Identity
Gene co-expression module in Neutrophils
| Category | Housekeeping |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes include TYROBP (DAP12, myeloid signaling adaptor), IFITM2 (interferon-induced transmembrane protein), HLA-C and HLA-E (MHC class I), S100A11 (alarmin/Ca-binding), CKLF (chemokine-like factor), LST1 (leukocyte-specific transcript), ITM2B, CMTM2, ANP32A, MYL12A. This constellation is characteristic of baseline myeloid/neutrophil housekeeping and surface identity genes including MHC-I antigen presentation components and myeloid lineage markers. TYROBP and LST1 are canonical myeloid markers. The uniform expression across subsets and high pct positive (72%) suggest constitutive expression. This module reflects a core myeloid identity/housekeeping program.
Genes
ANP32A, CKLF, CMTM2, HLA-C, HLA-E, IFITM2, ITM2B, LST1, MYL12A, RGS2, S100A11, TYROBP
Most correlated modules
- Neutrophil Chemotaxis Receptors · correlation 0.79
- Neutrophil Motility Cytoskeleton · correlation 0.71
- Bacterial Phagocytosis Program · correlation 0.70
- Neutrophil Survival Program · correlation 0.69
- Interferon Stimulated Genes · correlation 0.67
- Mature Neutrophil Activation · correlation 0.65
- Myeloid Inflammatory Activation · correlation 0.64
- Phagocytic Membrane Signaling · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.