Neutrophil Chemotaxis Receptors
Gene co-expression module in Neutrophils
| Category | Chemotaxis |
|---|---|
| Genes | 9 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Top hub EVI2B is highly expressed in myeloid progenitors and mature granulocytes. FCGR3B (CD16b, neutrophil-specific Fc receptor) and FCGR3A (CD16a) mediate antibody-dependent functions. CXCR1 and CXCR2 are the principal IL-8/CXCL8 receptors that drive neutrophil chemotaxis and are canonical neutrophil markers. CEBPD is a key granulocyte transcription factor. WAS (Wiskott-Aldrich syndrome protein) links receptor signaling to actin polymerization. YPEL3 is involved in cell senescence/aging. NRBF2 is an autophagy regulator. This module represents mature neutrophil receptor identity with CXCR chemotaxis receptors and Fc receptors as central features.
Genes
CEBPD, CXCR1, CXCR2, EVI2B, FCGR3A, FCGR3B, NRBF2, WAS, YPEL3
Most correlated modules
- Mature Neutrophil Identity · correlation 0.89
- TLR Lipid Signaling · correlation 0.88
- Innate DNA Sensing ISG · correlation 0.83
- Neutrophil Motility Cytoskeleton · correlation 0.81
- Myeloid Identity · correlation 0.79
- Neutrophil Differentiation · correlation 0.78
- Bacterial Phagocytosis Program · correlation 0.77
- Interferon Stimulated Genes · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.