TGF-beta Survival
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 6 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes include BCL2L11 (pro-apoptotic BH3-only protein), TGFBR1 (TGF-β receptor), TNFRSF1B (TNF receptor 2), MAP2K3 (p38 MAPK kinase), IRF4 (immune transcription factor), and KLF3 (transcriptional repressor). The combination of apoptosis regulators and cytokine receptors suggests a survival/cytokine signaling program, but all genes show weak membership and uniform expression, indicating a poorly defined mixed module. The TGF-β and apoptosis themes are the most coherent thread.
Genes
Most correlated modules
- Autophagy Cytoskeletal · correlation 0.92
- Chemokine Migration Response · correlation 0.91
- pDC Activation Response · correlation 0.87
- Transcriptional Regulation · correlation 0.84
- RNA Processing · correlation 0.84
- Glucocorticoid Receptor · correlation 0.82
- Transcriptional Repression · correlation 0.79
- NF-κB Immune Signaling · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.