General Housekeeping
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 20 of 21 genes have a known function matching the annotation |
Why this annotation
This module contains genes spanning proteasome subunits (PSMD8, PSMB6), actin cytoskeleton regulators (ARPC3, CFL1, BRK1, PFN1), glycolysis (PGK1, TALDO1), nuclear transport (RAN), vacuolar ATPase (ATP6V0B), RNA splicing (LSM4), ESCRT machinery (SNF8, CHMP2A), mitochondrial ribosome (MRPS15, MRPL28), and other housekeeping functions. All genes show uniform expression and weak membership, indicating a poorly defined but broadly expressed housekeeping module. The mix of cytoskeletal, metabolic, and proteostasis genes without a dominant pathway suggests a general housekeeping program rather than a specific biological response.
Genes
Most correlated modules
- Actin Cytoskeleton · correlation 0.89
- Lysosomal mTOR Signaling · correlation 0.88
- Mitochondrial Assembly · correlation 0.86
- ER-Golgi Trafficking · correlation 0.86
- Translation Initiation · correlation 0.84
- Mitochondrial Ribosome · correlation 0.84
- ER-Golgi Trafficking · correlation 0.83
- General Cellular Maintenance · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.