Type I Interferon
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Antiviral |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 26 genes have a known function matching the annotation |
Why this annotation
IRF7 (master transcription factor for type I interferon production, the defining functional program of pDCs), LILRA4 (BDCA-2/ILT7, canonical pDC surface receptor that suppresses TLR-driven IFN when engaged), PLD4 (phospholipase D4, pDC-specific marker involved in TLR9 signaling), SPIB (ETS transcription factor essential for pDC development and IFN production), GZMB (granzyme B, produced by activated pDCs as cytotoxic effector), UNC93B1 (chaperone for endosomal TLRs 7/8/9, critical for pDC innate sensing), JCHAIN (joining chain for IgA/IgM, expressed in pDCs), ALOX5AP (arachidonate 5-lipoxygenase activating protein, inflammatory lipid mediator). This module captures the core pDC antiviral/type I IFN identity program. Neighbor M60 (CLEC4C, IRF8) confirms the pDC identity neighborhood.
Genes
Most correlated modules
- MHC-I Presentation · correlation 0.86
- ER Redox Homeostasis · correlation 0.86
- ER Protein Folding · correlation 0.82
- pDC Identity · correlation 0.80
- Lysosomal Ag Processing · correlation 0.78
- Mitochondrial Import · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.