Actin Cytoskeleton
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 17 genes have a known function matching the annotation |
Why this annotation
This module is a neighbor of M13 and similarly shows uniform, weak expression across all subsets. Hub genes include ARPC4 (Arp2/3 complex, actin branching), ACTB (actin), CORO1A (coronin, actin organization), RHOC (Rho GTPase, cytoskeletal signaling), and VPS28 (ESCRT-I, vesicular trafficking). Additional genes include ECH1 (fatty acid oxidation), NDUFAF3 (mitochondrial complex I assembly), GALK1 (galactose metabolism), and RNA/chromatin regulators (METTL5, METTL26, TAF10, TSR3). The actin/cytoskeletal genes (ARPC4, ACTB, CORO1A, RHOC) are the most coherent sub-theme, but the module is mixed. Given the neighborhood context with M13 (also housekeeping/cytoskeletal), this module likely represents a related general housekeeping program with cytoskeletal emphasis.
Genes
Most correlated modules
- Lysosomal mTOR Signaling · correlation 0.91
- General Cellular Maintenance · correlation 0.90
- General Housekeeping · correlation 0.89
- Mitochondrial Assembly · correlation 0.87
- ER-Golgi Trafficking · correlation 0.84
- Mitochondrial Ribosome · correlation 0.84
- ER-Golgi Trafficking · correlation 0.83
- Oxidative Stress Response · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.