Metabolic Housekeeping
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 7 of 19 genes have a known function matching the annotation |
Why this annotation
GART encodes a trifunctional enzyme in de novo purine biosynthesis (a key housekeeping/proliferative metabolic pathway). GCLC (glutamate-cysteine ligase, rate-limiting step in glutathione synthesis, stress response/redox). PITPNB (phosphatidylinositol transfer protein, lipid metabolism). SNX4 (sorting nexin, endosomal trafficking). LTN1 (listerin E3 ubiquitin ligase, ribosome quality control). LYPLA1 (acyl-protein thioesterase). The module is metabolically diverse with no tight single program. Purine synthesis and glutathione metabolism are the most coherent functional threads.
Genes
Most correlated modules
- M18 · correlation 0.90
- Vesicular Immune Signaling · correlation 0.89
- Mixed Regulatory · correlation 0.82
- pDC Identity Signaling · correlation 0.82
- Centrosome DNA Damage · correlation 0.81
- Immune Cell Migration · correlation 0.79
- Epigenetic Silencing · correlation 0.78
- Ubiquitin Proteasome · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.