ER Redox Homeostasis
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 11 of 20 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression across subsets, indicating a poorly defined module. Hub genes include ER-resident proteins (SPCS1, ERP29, CNPY3, SELENOF, TXNDC12), oxidative stress/redox genes (CAT, UCP2, PARK7), RNases (RNASE6, RNASET2), and general housekeeping components. The dominant theme is ER protein processing and cellular redox homeostasis, but the weak coherence and uniform expression suggest this is a constitutive housekeeping program rather than a specific regulated state.
Genes
Most correlated modules
- ER Protein Folding · correlation 0.94
- MHC-I Presentation · correlation 0.91
- Lysosomal mTOR Signaling · correlation 0.91
- Fc Receptor Trafficking · correlation 0.90
- ER-Golgi Trafficking · correlation 0.90
- Metabolic Housekeeping · correlation 0.88
- Clathrin-mediated Endocytosis · correlation 0.87
- Type I Interferon · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.