Centrosome DNA Damage
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Proliferation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes PCNT (pericentrin, centrosome scaffold), CEP78 (centriole biogenesis), CCSAP (centriole/cilia), DCLRE1C (Artemis, DNA repair endonuclease), RAD17 (DNA damage checkpoint clamp loader), POLK (translesion DNA polymerase), and MIEF1 (mitochondrial fission/elongation) point to centrosome biology and DNA damage response. The co-occurrence of centrosome and DNA repair genes is consistent with cell cycle checkpoint programs. Despite weak membership, the functional clustering around centrosome/DNA damage is notable.
Genes
Most correlated modules
- Chromatin RNA Regulation · correlation 0.95
- Chromatin & Ubiquitin · correlation 0.87
- DNA Repair Housekeeping · correlation 0.87
- Vesicular Immune Signaling · correlation 0.86
- pDC Identity Signaling · correlation 0.82
- Metabolic Housekeeping · correlation 0.81
- Actin Cytoskeleton · correlation 0.78
- Epigenetic Silencing · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.