Actin Cytoskeleton
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes NSF (vesicle fusion ATPase), ARHGEF6 (Rho GEF activating Rac1/Cdc42), ACTR2 (Arp2/3 actin nucleation complex), MYO18A (unconventional myosin), MAP4 (microtubule-associated protein), and FNBP1 (formin-binding, actin/membrane dynamics) collectively define an actin cytoskeletal and vesicular trafficking program. PTPRC (CD45) is a major immune phosphatase. NUP214 (nuclear pore) and NCOR1 are peripheral. The actin dynamics theme (ARHGEF6, ACTR2, MYO18A, MAP4, FNBP1) is the most coherent signal. NSF adds a vesicular component. Uniform weak expression across subsets suggests a constitutive cytoskeletal housekeeping program.
Genes
Most correlated modules
- Mixed Regulatory Background · correlation 0.87
- DNA Damage Response · correlation 0.86
- Polycomb Transcription · correlation 0.86
- pDC Identity Signaling · correlation 0.85
- DNA Repair Housekeeping · correlation 0.84
- Chromatin Remodeling · correlation 0.84
- pDC Identity & Splicing · correlation 0.84
- Chromatin & Ubiquitin · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.