Transcriptional Regulation
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes include ZBTB33 (transcriptional repressor/chromatin organizer), ETS1 (transcription factor), DR1 (transcriptional corepressor), UBTF (RNA Pol I transcription factor), RBBP4 (chromatin assembly/NuRD complex), MSL3 (histone acetyltransferase complex), CNOT7 (CCR4-NOT deadenylase complex), CUL4B (E3 ubiquitin ligase for chromatin). The module is dominated by transcriptional regulators and chromatin-modifying factors. All genes show weak membership and uniform expression, indicating a loosely co-expressed housekeeping transcriptional regulation program rather than a specific biological response.
Genes
Most correlated modules
- Endosomal Trafficking · correlation 0.93
- Cell Cycle Regulation · correlation 0.92
- Monocyte Chemotaxis · correlation 0.92
- IFN Receptor Signaling · correlation 0.91
- DNA Repair & Chromatin · correlation 0.90
- ER Protein Folding · correlation 0.89
- Mixed Regulatory · correlation 0.88
- ER Quality Control · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.