ER Quality Control
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 4 of 19 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression. Hub genes include CLTC (clathrin heavy chain, endocytosis/vesicular trafficking), SEL1L (ER-associated degradation/ERAD), DNAJC10 (ER chaperone/ERAD), TMX3 (ER oxidoreductase), PRKAR1A (PKA regulatory subunit), SLK (serine/threonine kinase), TPR (nuclear pore), SMARCC2 (SWI/SNF chromatin remodeling), GTF2A1/GTF3C1 (general transcription factors), VIRMA (m6A methylation), CD46 (complement regulatory protein). The strongest functional thread is ER quality control and vesicular trafficking (CLTC, SEL1L, DNAJC10, TMX3), but the module is too heterogeneous for a tight label. Given CLTC as top hub and SEL1L/DNAJC10/TMX3 supporting ER/vesicular themes, vesicular trafficking is the best fit. Weak coherence and uniform expression confirm this is a loosely defined housekeeping module.
Genes
Most correlated modules
- Genome Organization · correlation 0.91
- Ubiquitin-Proteasome Regulation · correlation 0.91
- DNA Repair & Chromatin · correlation 0.90
- Endosomal Trafficking · correlation 0.87
- Transcriptional Regulation · correlation 0.86
- RNA Processing · correlation 0.86
- Lipid Transport & Membrane · correlation 0.84
- IFN Receptor Signaling · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.