Transcription & Splicing
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 32 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression. Hub genes include BROX (ESCRT-III associated), PRPF8 (pre-mRNA splicing factor, spliceosome), ZMAT2 (splicing), SUPT16H (FACT complex, chromatin/transcription elongation), THRAP3 (transcription coactivator), BRD8 (chromatin remodeling), LARP7 (7SK snRNP, transcription regulation), POLR2B (RNA Pol II subunit), XPC (nucleotide excision repair), EPRS1 (aminoacyl-tRNA synthetase), ITGB1 (integrin beta-1, adhesion), ATL3 (ER morphology GTPase), GMFB (actin dynamics). The strongest theme is transcription and RNA processing (PRPF8, ZMAT2, SUPT16H, THRAP3, BRD8, LARP7, POLR2B), with secondary DNA repair (XPC) and ER/cytoskeletal components. This is a loosely co-expressed housekeeping transcription/splicing module. Neighbor context of similarly weak modules supports this interpretation.
Genes
Most correlated modules
- Lipid Transport & Membrane · correlation 0.81
- Ubiquitin Proteasome · correlation 0.80
- DNA Repair & Chromatin · correlation 0.76
- DNA Damage Response · correlation 0.72
- Mixed Regulatory Background · correlation 0.70
- Histone Expression · correlation 0.66
- RNA Processing · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.