Rho GEF Migration
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Migration & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 5 of 11 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression. Hub genes include DOCK10 (dedicator of cytokinesis 10, Cdc42/Rac GEF, lymphocyte migration), DMD (dystrophin, cytoskeletal scaffolding), NUP153 (nuclear pore), RAB30 (Rab GTPase, vesicular trafficking), VAV2 (Rho/Rac GEF, cytoskeletal signaling), TET3 (DNA demethylase), and RUFY3 (Rab7-interacting, endosomal). DOCK10 and VAV2 are both Rho-family GEFs involved in cytoskeletal reorganization and lymphocyte migration; DMD provides cytoskeletal scaffolding. This is the most coherent sub-theme, though the module overall is weakly defined. As a neighbor to M90 (also DOCK1-containing), the shared DOCK-family GEF theme supports a cytoskeletal/migration program.
Genes
Most correlated modules
- Metabolic Stress Response · correlation 0.88
- Cell Cycle Regulation · correlation 0.84
- Rho GEF Signaling · correlation 0.82
- ARF-mediated Trafficking · correlation 0.76
- Zinc Finger Transcription · correlation 0.76
- Mixed Regulatory · correlation 0.74
- Epigenetic Regulation · correlation 0.70
- Cell Cycle Regulation · correlation 0.58
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.