Complex I Subunits
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 29 genes have a known function matching the annotation |
Why this annotation
This module is dominated by NADH dehydrogenase Complex I subunits: NDUFB7, NDUFB10, NDUFA4, NDUFB2, NDUFB8, NDUFS6. Additionally COX7B and COX6C are Complex IV subunits, and MRPL52 is a mitochondrial ribosomal protein. ROMO1 is a mitochondrial inner membrane protein. KRT10 (keratin) and GTF2A2 are outliers. The module is clearly enriched for respiratory chain Complex I subunits, consistent with the OxPhos neighborhood.
Genes
Most correlated modules
- Mitochondrial Ribosome · correlation 0.89
- Respiratory Chain · correlation 0.89
- Mitochondrial Assembly · correlation 0.82
- Complex I Assembly · correlation 0.81
- Mitochondrial Import · correlation 0.81
- ER-Golgi Trafficking · correlation 0.78
- ATP Synthase Complex · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.