Mitochondrial Assembly
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes COX4I1 and SURF1 are core mitochondrial complex IV components; ATP6V1G1 is V-ATPase subunit; PYURF is a complex I/mitochondrial assembly factor; C1QBP is a mitochondrial ribosome-associated protein. GABARAPL2 links to mitophagy. EIF3K/EIF3M add translation initiation. All genes show weak membership and uniform expression, indicating a loosely co-expressed housekeeping module centered on mitochondrial oxidative phosphorylation and assembly. Neighbor modules share similar housekeeping character.
Genes
Most correlated modules
- Lysosomal mTOR Signaling · correlation 0.92
- Mitochondrial Ribosome · correlation 0.88
- General Cellular Maintenance · correlation 0.88
- Actin Cytoskeleton · correlation 0.87
- General Housekeeping · correlation 0.86
- Fc Receptor Trafficking · correlation 0.86
- ER Redox Homeostasis · correlation 0.86
- ER-Golgi Trafficking · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.