Survival & Adhesion
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 6 of 19 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression, indicating a poorly defined module. The gene mix includes LMNA (nuclear lamina), PLIN2 (lipid droplet coating), ITGA5 (integrin-mediated adhesion), VPS37B (ESCRT/vesicle sorting), BCL2 (survival), SLC16A1 (metabolite transport), and HBEGF (growth factor signaling). No single tight program dominates; the module loosely reflects cell survival and adhesion-related housekeeping functions. Neighbor context of similarly weak modules supports a low-confidence, mixed housekeeping interpretation.
Genes
Most correlated modules
- Hematopoietic Development · correlation 0.88
- Post-transcriptional Regulation · correlation 0.79
- Mitotic Cell Cycle · correlation 0.78
- Mixed Signaling · correlation 0.77
- Progenitor Transcription · correlation 0.77
- Stress & Apoptotic Priming · correlation 0.73
- Myeloid Differentiation · correlation 0.72
- Glycolytic Metabolism · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.