pDC Activation Response
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 15 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes NR4A1/2/3, FOSL2, CREM, ATF3 are immediate-early transcription factors induced by cellular activation via NF-κB and AP-1 pathways. Supporting genes CD83 (DC maturation marker), ICAM1 (adhesion/activation), MALT1 (NF-κB signaling), REL (NF-κB subunit), DUSP2 (phosphatase in immune activation), KDM6B (epigenetic activation), ETV3, NFE2L2, ZNF331, ZC3HAV1 all fit a pDC activation/maturation transcriptional program. Neighbor M124 shares AP-1 members (JUNB/JUND) and NF-κB components, supporting a coordinated activation program across both modules.
Genes
Most correlated modules
- Chemokine Migration Response · correlation 0.96
- Heat Shock Response · correlation 0.92
- Autophagy Cytoskeletal · correlation 0.89
- TGF-beta Survival · correlation 0.87
- DC Maturation Migration · correlation 0.84
- Glucocorticoid Receptor · correlation 0.81
- NF-κB Immune Signaling · correlation 0.81
- Transcriptional Regulation · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.