Lysosomal Ag Processing
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Ag processing & presentation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 18 genes have a known function matching the annotation |
Why this annotation
CTSS (cathepsin S, the key protease for MHC-II invariant chain clipping and antigen processing in pDCs and DCs), PSAP (prosaposin, lysosomal sphingolipid activator and protease cofactor), M6PR (mannose-6-phosphate receptor, essential for lysosomal enzyme targeting), MYCL (L-Myc, transcription factor highly expressed in pDCs and required for pDC function), MS4A6A (MS4A family member expressed in myeloid/pDC cells), PLEK (pleckstrin, myeloid signaling), NLRP7 (inflammasome component). The module centers on lysosomal antigen processing (CTSS, PSAP, M6PR) with pDC-specific transcriptional identity (MYCL). Neighbor M108 (MHC-I) and M60 (pDC identity) confirm this is part of an antigen processing/pDC identity neighborhood.
Genes
Most correlated modules
- Fc Receptor Trafficking · correlation 0.85
- pDC Identity · correlation 0.83
- Monocyte Chemotaxis · correlation 0.82
- Metabolic Housekeeping · correlation 0.81
- Type I Interferon · correlation 0.78
- MHC-I Presentation · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.