Chromatin Remodeling
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 28 genes have a known function matching the annotation |
Why this annotation
Hub genes include ZNF236, ZNF169, ZBTB11 (zinc finger transcriptional repressors), SMARCA4 (SWI/SNF chromatin remodeling ATPase), CCNK (cyclin K, transcription-coupled), RNF4 (SUMO-targeted ubiquitin E3 ligase, chromatin regulation), UBN1 (HIRA histone chaperone complex), MED23 (Mediator complex). SRSF10 and DHX57 add RNA processing. The dominant theme is chromatin remodeling and transcriptional regulation via SWI/SNF and associated factors. All genes are weak/uniform, consistent with a housekeeping transcriptional regulation cluster.
Genes
Most correlated modules
- JAK-STAT Signaling · correlation 0.80
- Antiviral Innate Sensing · correlation 0.79
- RNA Splicing Regulation · correlation 0.78
- pDC Identity & Splicing · correlation 0.77
- Transcription Regulation · correlation 0.76
- Cell Cycle Regulation · correlation 0.76
- RNA Processing · correlation 0.71
- Epigenetic Regulation · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.