Zinc Finger Transcription
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 5 of 30 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression. Hub genes include ZNF740, ZNF280D, ZNF594, ZXDC (multiple zinc finger transcription factors), FANCM (Fanconi anemia complementation group M, DNA repair helicase), INTS8 (integrator complex, RNA Pol II regulation), and OSBPL1A/SGMS1 (lipid metabolism). The dominant theme among hub genes is transcriptional regulation via zinc finger proteins, with a secondary DNA repair component. The module is poorly defined and heterogeneous.
Genes
Most correlated modules
- Rho GEF Signaling · correlation 0.93
- ARF-mediated Trafficking · correlation 0.91
- Cell Cycle Regulation · correlation 0.89
- Polycomb Transcription · correlation 0.80
- Mixed Regulatory Background · correlation 0.79
- DNA Damage Response · correlation 0.78
- Rho GEF Migration · correlation 0.76
- Mixed Regulatory Background · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.