Respiratory Chain
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 34 genes have a known function matching the annotation |
Why this annotation
This module is heavily enriched for respiratory chain subunits: COX8A, COX6B1, COX7A2, COX5B, COX7C (Complex IV); NDUFB11, NDUFB4, NDUFA1, NDUFA11, NDUFA3 (Complex I); UQCR11, UQCRQ (Complex III). Additional genes include splicing factors (SNRPD2, LSM7, POLR2L) and ANAPC11 (APC/C ubiquitin ligase). The dominant program is oxidative phosphorylation respiratory chain, spanning Complexes I, III, and IV.
Genes
Most correlated modules
- Mitochondrial Import · correlation 0.92
- Mitochondrial Ribosome · correlation 0.91
- Complex I Subunits · correlation 0.89
- Complex I Assembly · correlation 0.88
- Mitochondrial Assembly · correlation 0.78
- ATP Synthase Complex · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.