Unfolded Protein Response
Gene co-expression module in Plasma cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
HSPA5 (BiP) is the master UPR regulator and a top hub. HYOU1 is an ER chaperone induced by UPR. ERLEC1 is an ER lectin involved in glycoprotein quality control. MZB1 is a plasma cell-specific ER protein that facilitates IgM secretion and UPR. HM13 is a signal peptidase. CRELD2 is a well-established UPR/ER stress marker. MTHFD2, PHGDH, and SHMT2 are one-carbon/serine metabolism enzymes upregulated during ER stress and rapid secretory cell growth. CD38 marks plasma cell identity. EIF4EBP1 reflects mTOR-mediated translational control. Weak coherence reflects mixing of UPR with metabolic reprogramming, but the dominant signal is ER stress/UPR in secretory plasma cells.
Genes
Most correlated modules
- ER Protein Folding · correlation 0.92
- ER-Golgi Secretory Pathway · correlation 0.91
- N-glycosylation ER · correlation 0.90
- Plasmablast Differentiation · correlation 0.83
- ER Protein Folding · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.