Plasmablast Proliferation
Gene co-expression module in Plasma cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 11 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include LMNB2 (nuclear lamina, cell cycle), RCC1 (RanGEF, mitosis), CKAP5 (microtubule polymerase, spindle), KIF2A (kinesin, mitosis), RECQL (DNA helicase), alongside RNA processing genes CPSF2, SF3B3, POLR3H. The strongest plasmablast enrichments are for cell cycle genes (LMNB2 9x, CKAP5 7.1x, RCC1 6.7x). Weak coherence reflects a mixed module, but the dominant program is cell cycle/mitotic machinery in proliferating plasmablasts. Upregulated with inflammation and not reversed by treatment.
Genes
Most correlated modules
- Chromatin Remodeling · correlation 0.97
- Mitochondrial Biogenesis · correlation 0.96
- Plasmablast Trafficking · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.