Mitochondrial Biogenesis
Gene co-expression module in Plasma cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
Top hub UQCRC1 (mitochondrial Complex III), NDUFS8 (Complex I), TIMM17A (mitochondrial inner membrane translocase) indicate mitochondrial OxPhos/biogenesis. PSMC2 (proteasome 26S ATPase) and NCAPD3 (condensin II, mitosis, 14.3x enrichment) add proteasomal and cell cycle components. LBR (lamin B receptor, nuclear envelope/cell cycle) and ENSA (PP2A regulator in mitosis) further support proliferation. Moderate coherence. The combination of mitochondrial and cell cycle genes reflects metabolic demands of rapidly proliferating plasmablasts during inflammation. Strong delta_inflammation signal.
Genes
Most correlated modules
- Ribosome Biogenesis · correlation 0.96
- Plasmablast Proliferation · correlation 0.96
- hnRNP RNA Processing · correlation 0.96
- RNA Splicing Processing · correlation 0.96
- Housekeeping Mixed · correlation 0.96
- Actin Cytoskeletal Dynamics · correlation 0.95
- Chromatin Remodeling · correlation 0.95
- Chaperonin Protein Folding · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.