Chromatin Remodeling
Gene co-expression module in Plasma cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 18 genes have a known function matching the annotation |
Why this annotation
HELLS (helicase lymphoid-specific, chromatin remodeling for DNA replication, 20.7x plasmablast enrichment) is the most plasmablast-enriched gene. BOP1 and GPATCH4 support ribosome biogenesis/rRNA processing. CENPX (centromere protein, kinetochore), CCDC124 (cytokinesis), TEDC1 (centriole biogenesis), ARPP19 (PP2A inhibitor, mitotic entry) are cell cycle genes. BRD9 (SWI/SNF chromatin remodeling) and TRIM28 (KAP1, chromatin silencing) add chromatin regulation. Weak coherence but dominated by chromatin remodeling and cell cycle programs in proliferating plasmablasts.
Genes
Most correlated modules
- Plasmablast Proliferation · correlation 0.97
- Mitochondrial Biogenesis · correlation 0.95
- Nuclear Transport Chromatin · correlation 0.93
- Ribosome Biogenesis · correlation 0.93
- Plasmablast Trafficking · correlation 0.93
- Ribosome Biogenesis · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.