Plasmablast Trafficking
Gene co-expression module in Plasma cells
| Category | migration & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 14 genes have a known function matching the annotation |
Why this annotation
This weakly coherent module contains CXCR3 (chemokine receptor directing lymphocyte homing to inflamed tissues) and S1PR4 (sphingosine-1-phosphate receptor regulating lymphocyte egress and trafficking), both key regulators of plasmablast/lymphocyte migration. TACC1 (centrosome-associated), ACTN4 (cytoskeletal crosslinker), and PLEKHO1 (PH domain signaling) add cytoskeletal/motility context. EIF4EBP2 and UBTF suggest translational and transcriptional activity. The weak coherence and heterogeneous membership indicate a loosely co-regulated program. The plasmablast enrichment of CXCR3 (5.3x) and S1PR4 (3.7x) anchors this as a plasmablast trafficking/homing module. Neighbor M39 shares plasmablast enrichment but focuses on innate immune signals, supporting that M58 captures a distinct migratory program.
Genes
Most correlated modules
- Nuclear Transport Chromatin · correlation 0.95
- Plasmablast Apoptosis · correlation 0.95
- Nuclear Export Replication · correlation 0.95
- RNA Splicing Processing · correlation 0.95
- Polyamine Biosynthesis · correlation 0.95
- Plasmablast Stress Activation · correlation 0.94
- Plasmablast Proliferation · correlation 0.94
- Chromatin Remodeling · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.