Stress Transcriptional Response
Gene co-expression module in Tuft cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes include SGK1 (serum/glucocorticoid-regulated kinase, stress and hypoxia response), GADD45B (growth arrest and DNA damage response, stress-induced), ADM (adrenomedullin, hypoxia/stress peptide), CITED2 (HIF-1 coactivator, hypoxia transcription), HSPA2 (heat shock protein), CSRNP2 (stress-responsive transcription factor), BRD2 (bromodomain chromatin reader, stress gene activation), POLR2A (RNA Pol II, transcriptional machinery), RASD1 (RAS-related, immediate early gene), DLL4 (Notch ligand), DALRD3 (tRNA modification), PLK2 (polo-like kinase, stress response). The convergence of SGK1, GADD45B, ADM, CITED2, and HSPA2 strongly points to a stress-activated transcriptional response program, potentially hypoxia/inflammatory stress. Upregulated in CD, reduced by treatment.
Genes
Most correlated modules
- Immediate Early Stress · correlation 0.64
- Transcription Elongation Control · correlation 0.64
- Cholinergic Tuft Signaling · correlation 0.55
- Tuft Cell Identity · correlation 0.48
- Septin Cytoskeletal Organization · correlation 0.47
- Tuft Lipid Secretion · correlation 0.46
- Innate Immune Sensing · correlation 0.45
- Heat Shock Stress Response · correlation 0.39
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.