Complex I Antioxidant OxPhos
Gene co-expression module in Tuft cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
All 8 genes are enriched in pre_tuft cells (~2.2-3.5x). Hub genes include NDUFS7 and NDUFS6 (NADH:ubiquinone oxidoreductase iron-sulfur protein subunits, Complex I), NDUFA1 and NDUFB3 (Complex I subunits), ATP5F1E (ATP synthase subunit epsilon, Complex V), GPX4 (glutathione peroxidase 4, lipid peroxide reduction, ferroptosis defense), YBX1 (Y-box binding protein 1, RNA binding/translation regulation), WDR83OS. The module is dominated by mitochondrial Complex I and ATP synthase subunits, with GPX4 adding a mitochondrial antioxidant/ferroptosis defense component. YBX1 is a pleiotropic RNA-binding protein. This is a tight OxPhos/Complex I module with antioxidant features in pre-tuft progenitors, consistent with all neighboring modules in this batch.
Genes
Most correlated modules
- Mitochondrial Housekeeping · correlation 0.96
- ER Vesicle Trafficking · correlation 0.94
- Respiratory Chain OxPhos · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.