Respiratory Chain OxPhos
Gene co-expression module in Tuft cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 15 genes have a known function matching the annotation |
Why this annotation
All 15 genes are enriched in pre_tuft cells (~2.1-3.7x). Hub genes include COX7B (cytochrome c oxidase subunit 7B, Complex IV), ATP5ME (ATP synthase subunit epsilon, Complex V), NDUFB8, NDUFA4, NDUFA11, NDUFB2, NDUFB7 (multiple Complex I subunits), TMA7 (translation machinery associated), PHPT1 (phosphohistidine phosphatase), RBX1 (RING-box protein 1, SCF E3 ubiquitin ligase), TBCA (tubulin-specific chaperone A), PNKD (paroxysmal nonkinesigenic dyskinesia protein), TSTD1 (thiosulfate sulfurtransferase), COX6A1 (cytochrome c oxidase subunit 6A1, Complex IV), SNRPD3 (small nuclear ribonucleoprotein D3). The module is dominated by mitochondrial respiratory chain subunits from Complexes I, IV, and V, making this a clear OxPhos module enriched in pre_tuft progenitors.
Genes
Most correlated modules
- Mitochondrial OxPhos Complex I · correlation 0.98
- Mitochondrial Translation · correlation 0.96
- Mitochondrial OxPhos Assembly · correlation 0.96
- ER Membrane Biogenesis · correlation 0.94
- Pre-tuft Mitochondrial Metabolic · correlation 0.94
- Mixed OxPhos Secretory · correlation 0.94
- RNA Splicing Translation · correlation 0.93
- Mitochondrial Housekeeping · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.