Mitochondrial Housekeeping
Gene co-expression module in Tuft cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 12 genes have a known function matching the annotation |
Why this annotation
All 12 genes are enriched in pre_tuft cells (~2.9-4.2x). Hub genes include NDUFA6 (Complex I subunit), MRPL22 (mitochondrial ribosomal protein), AP2S1 (adaptor protein complex 2 sigma subunit, clathrin-mediated endocytosis), HIGD2A (HIG domain family member, cytochrome c oxidase assembly), POLR2F (RNA polymerase II subunit), COPS9 (COP9 signalosome subunit), TMEM258 (ER membrane protein, N-glycosylation), ATP5MF (ATP synthase subunit f, Complex V), UXT (ubiquitously expressed prefoldin-like chaperone), ANAPC11 (APC/C E3 ubiquitin ligase subunit), ALKBH7 (mitochondrial tRNA modification), DCTPP1 (dCTP pyrophosphatase). The module combines mitochondrial OxPhos (NDUFA6, HIGD2A, ATP5MF, ALKBH7), mitochondrial ribosome (MRPL22), and general housekeeping functions. Consistent with the pre_tuft neighborhood of mitochondrial modules.
Genes
Most correlated modules
- ER Vesicle Trafficking · correlation 0.97
- Translation Initiation · correlation 0.97
- Mitochondrial OxPhos Complex I · correlation 0.97
- Pre-tuft Progenitor Metabolism · correlation 0.96
- Progenitor Cell Proliferation · correlation 0.96
- Complex I Antioxidant OxPhos · correlation 0.96
- Mitotic Spindle Assembly · correlation 0.96
- Pre-tuft Mitochondrial Metabolic · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.