Pre-tuft Differentiation
Gene co-expression module in Tuft cells
| Category | Epithelial development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 12 genes have a known function matching the annotation |
Why this annotation
Genes highly enriched in pre_tuft (up to 10x). TMPRSS4 and CA12 are epithelial differentiation markers; LRIG3 is a receptor tyrosine kinase regulator involved in epithelial identity; PKP2 is a desmosomal component for cell-cell adhesion. ACADS, SQOR, NDUFAF4, ACOT13 represent mitochondrial fatty acid oxidation and Complex I assembly. PRKAR2A (PKA regulatory subunit) links to cAMP signaling relevant to tuft cell chemosensory function. This module captures epithelial identity establishment with metabolic maturation in pre-tuft progenitors.
Genes
Most correlated modules
- Pre-tuft WNT Secretion · correlation 0.96
- MYC-driven Biosynthesis · correlation 0.95
- Pre-tuft Biosynthetic · correlation 0.95
- RNA Splicing Translation · correlation 0.94
- Proliferating Mucus Secretory · correlation 0.93
- Mitochondrial Biogenesis · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.