MYC-driven Biosynthesis
Gene co-expression module in Tuft cells
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
MYC is the master regulator of biosynthetic and proliferative programs and is the most pre_tuft-enriched gene (23.3x). BRIX1 (ribosome biogenesis factor), MRPS6 (mitoribosome small subunit), SRPRB (SRP receptor beta, co-translational import), LAPTM4B (lysosomal/endosomal membrane protein upregulated by MYC), VAV3 (Rho GEF downstream of growth signals), SH3RF2 (JNK scaffold/E3 ligase), SPAG1 (dynein assembly/ciliogenesis — relevant to tuft cell cilia), GGCT (glutathione catabolism), PPIF (mitochondrial cyclophilin). The module represents a MYC-driven biosynthetic/proliferative program in pre-tuft progenitors.
Genes
Most correlated modules
- Pre-tuft Differentiation · correlation 0.95
- Progenitor S-phase · correlation 0.95
- Mitochondrial Biogenesis · correlation 0.94
- G2/M Progenitor Proliferation · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.