ABCB8 — ATP binding cassette subfamily B member 8
ABCB8 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ABCB8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Metabolic Homeostasis Nutrient processing | AMD1, CHCHD7, CLU, COQ7, FAM83E, IRF3, KIFC2, MAFA +13 more | View in SCUBA |
About the gene
| Synonyms | EST328128, M-ABC1, MABC1, MITOSUR |
|---|---|
| Chromosome | 7: 151028422-151047782 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Biological process | Ion transport, Potassium transport, Transport |
Function
ATP-binding subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)). Together with pore-forming subunit CCDC51/MITOK of the mitoK(ATP) channel, mediates ATP-dependent potassium currents across the mitochondrial inner membrane. An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix. Plays a role in mitochondrial iron transport. Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.