Metabolic Homeostasis
Gene co-expression module in Colonocytes
| Category | Nutrient metabolism |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 22 genes have a known function matching the annotation |
Why this annotation
Hub genes include TM7SF2 (sterol biosynthesis), COQ7 (ubiquinone biosynthesis), NADSYN1 (NAD+ synthesis), AMD1 (polyamine synthesis/S-adenosylmethionine decarboxylase), ABCB8 (mitochondrial iron/drug transporter), YME1L1 (mitochondrial AAA protease), CHCHD7 (mitochondrial), and MLST8 (mTORC1/2). The module represents a broad cellular metabolic homeostasis program spanning lipid/sterol synthesis, mitochondrial quality control, and cofactor biosynthesis. Uniform expression across colonocyte subsets. As a topological neighbor of M32 (mitochondrial ribosome), the shared mitochondrial components (COQ7, ABCB8, YME1L1) drive co-expression, while M144 extends into lipid and cofactor metabolism.
Genes
Most correlated modules
- Vesicular Trafficking · correlation 0.75
- RNA Splicing Regulation · correlation 0.71
- Stem Cell Epigenetic · correlation 0.71
- Cellular Senescence · correlation 0.69
- Ribosome Biogenesis · correlation 0.65
- P-TEFb Transcription Control · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.