COQ7 — Coenzyme Q7, hydroxylase
COQ7 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
COQ7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Mitochondrial Biogenesis Mitochondrial & OxPhos | ARFIP1, ARRDC3, COG2, DXO, EPM2AIP1, EPS8, HELQ, LETM2 +7 more | |
| Monocytes | AP-1 Inflammatory Activation Inflammatory | DUSP1, FOS, IER2, JUN, JUNB, KCNE1, KLF6, NAIP +2 more | View in SCUBA |
| Mucosal-associated invariant T cell | Mitochondrial Quality Control Mitochondrial & OxPhos | EPS8, LETM2, PATL2, SDR42E2, TBCC, YME1L1, ZBTB10 |
About the gene
| Synonyms | CAT5, CLK-1 |
|---|---|
| Chromosome | 16: 19067614-19080095 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Monooxygenase, Oxidoreductase |
| Biological process | Ubiquinone biosynthesis |
Function
Catalyzes the hydroxylation of the 5-methoxy-2-methyl-3-(all- trans-polyprenyl)benzoquinone at the C6 position and participates in the biosynthesis of ubiquinone (Probable). Catalyzes the reaction through a substrate-mediated reduction pathway, whereby NADH shuttles electrons to 5-methoxy-2-methyl-3-(all-trans-decaprenyl)benzoquinone, which then transfers the electrons to the two Fe(3+) centers. The binding of 5-methoxy-2-methyl-3-(all-trans- polyprenyl)benzoquinone (DMQn) mediates reduction of the diiron center by nicotinamide adenine dinucleotide (NADH) and initiates oxygen activation for subsequent DMQ hydroxylation. The physiological substrates are 5-methoxy-2-methyl-3-(all-trans- nonaprenyl)benzoquinone (DMQ(9)) and 5-methoxy-2-methyl-3-(all-trans- decaprenyl)benzoquinone (DMQ(10)), however in vitro the enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency. Also has a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner (By similarity). Plays a role in modulating mitochondrial stress responses, acting in the nucleus, perhaps via regulating gene expression, independent of its characterized mitochondrial function in ubiquinone biosynthesis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.