AMD1 — Adenosylmethionine decarboxylase 1

AMD1 belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

AMD1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Integrated Stress Response Stress	DDIT3, FAM133B, GOLGB1, IFRD1, MIDN, MKNK2, PHF1, PIM2 +4 more	View in SCUBA
CD4⁺ T cells	RNA processing RNA processing	AARSD1, ABHD14A, CALM2, CDKN2AIP, CHMP1B, FRAT1, HNRNPAB, HNRNPDL +7 more	View in SCUBA
Endothelial	Endothelial Quiescence Endothelial cell development	AQP7, ARMH4, CDC14B, FBXO34, GATA2, GLUL, KLF3, MTURN +7 more	View in SCUBA
Gamma-delta T cells	Heat Stress Apoptotic Stress	DBF4, DNAJB9, DUSP2, IER5, NFKBIB, NINJ1, PHLDA1, PMAIP1 +5 more
Glial cells	Hypoxia mTOR Stress Stress	CDKN2AIP, CITED2, DDIT4, HEXIM1, HSPA2, IFRD1, INTS6, NEU1 +3 more	View in SCUBA
Hematopoietic progenitor cells	HSC Progenitor Proliferation Stemness	CDK6, GNAQ, GSE1, MYB, RNF24, SPN, STAT5A, ZEB2
Innate lymphoid cells	Integrated Stress Response Stress	ATF4, CYCS, DDX5, DNAJB6, EIF1, GPBP1, HERPUD1, HNRNPH1 +3 more	View in SCUBA
Lymphatic endothelial	Stress Granule Assembly Stress	BHLHE40, CD55, CDKN1A, DDX3X, DUSP5, EIF4G2, ERF, FUS +3 more	View in SCUBA
Macrophages	General Cellular Maintenance Housekeeping	ABHD13, AKT2, C1GALT1, DCUN1D1, FBXL3, FMR1, GAK, GCC2 +13 more	View in SCUBA
Mucosal-associated invariant T cell	AP-1 Immediate Early Stress	BRD2, CITED2, CSKMT, FUS, GADD45B, GADD45G, H2AX, HEXIM1 +17 more
Natural Killer cells	EGR2/3 NK Activation activation	CHD4, CRTAM, CSF2, DNAJB9, EGR2, EGR3, GADD45A, MAP2K3 +4 more	View in SCUBA

About the gene

Synonyms	SAMDC
Chromosome	6: 110874770-110898879
Predicted location	Intracellular
Essential gene	No
Protein class	Enzymes, Metabolic proteins, Predicted intracellular proteins
Molecular function	Decarboxylase, Lyase
Biological process	Polyamine biosynthesis, Spermidine biosynthesis

Function

Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.